The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 30, 2025
Filed:
Sep. 21, 2023
Amgen Inc., Thousand Oaks, CA (US);
Vigil Neuroscience, Inc., Watertown, MA (US);
Lara C. Czabaniuk, Thousand Oaks, CA (US);
Timothy Hopper, Thousand Oaks, CA (US);
Jonathan B. Houze, Cambridge, MA (US);
Jane Panteleev, Thousand Oaks, CA (US);
Gwenaella Rescourio, Thousand Oaks, CA (US);
Vincent Santora, Thousand Oaks, CA (US);
Haoxuan Wang, Thousand Oaks, CA (US);
Ryan D. White, Thousand Oaks, CA (US);
Alice R. Wong, Thousand Oaks, CA (US);
Yongwei Wu, Thousand Oaks, CA (US);
Maxence Bos, Saint-Laurent, CA;
John Mancuso, Saint-Laurent, CA;
Ivan Franzoni, Saint-Laurent, CA;
AMGEN INC., Thousand Oaks, CA (US);
VIGIL NEUROSCIENCE, INC., Watertown, MA (US);
Abstract
The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2”). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.