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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12428406 B1

PDFFull Text
Date of Patent:
Sep. 30, 2025

Filed:

Jun. 02, 2023

Methods and compounds for restoring mutant p53 function

Applicant:

Pmv Pharmaceuticals, Inc., Princeton, NJ (US);

Inventors:

Binh Vu, North Caldwell, NJ (US);

Romyr Dominique, East Brunswick, NJ (US);

Hongju Li, Edison, NJ (US);

Bruce Fahr, East Windsor, NJ (US);

Andrew Good, Wallingford, CT (US);

Assignee:

PMV PHARMACEUTICALS, INC., Princeton, NJ (US);

Attorney:

WILSON SONSINI GOODRICH & ROSATI

Primary Examiner:

Pancham Bakshi

Int. Cl.
CPC ...
C07D 405/14 (2006.01); C07D 209/14 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/06 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01); C07D 409/14 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); C07D 471/08 (2006.01); C07D 491/107 (2006.01); C07F 7/08 (2006.01); C07H 15/26 (2006.01);
U.S. Cl.
CPC ...
C07D 405/14 (2013.01); C07D 209/14 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/06 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 471/08 (2013.01); C07D 491/107 (2013.01); C07F 7/0812 (2013.01); C07H 15/26 (2013.01);
Abstract

Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

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