The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 30, 2025

Filed:

May. 07, 2021
Applicant:

Merck Sharp & Dohme Llc, Rahway, NJ (US);

Inventors:

Jacqueline D. Hicks, Watchung, NJ (US);

John S. Debenham, Scotch Plains, NJ (US);

Amjad Ali, Freehold, NJ (US);

Ying-Duo Gao, Middletown, NJ (US);

Lan Wei, Berkeley Heights, NJ (US);

Dexi Yang, Livingston, NJ (US);

Rongze Kuang, Green Brook, NJ (US);

Alan Hruza, Hackettstown, NJ (US);

Peter Nizner, Fanwood, NJ (US);

Daniel A. Tatosian, Berkeley Heights, NJ (US);

Assignee:

Merck Sharp & Dohme LLC, Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/14 (2006.01); C07D 417/14 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); C07D 417/14 (2013.01);
Abstract

The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XI activation inhibitors.


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