The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 30, 2025
Filed:
Jan. 28, 2022
Rapt Therapeutics, Inc., South San Francisco, CA (US);
Cyril Bucher, San Mateo, CA (US);
James P. Davidson, South San Francisco, CA (US);
Jeffrey J. Jackson, San Bruno, CA (US);
Michelle Yoo Min Ko, San Francisco, CA (US);
Grant Shibuya, South San Francisco, CA (US);
David J. Wustrow, South San Francisco, CA (US);
Ashkaan Younai, Daly City, CA (US);
Mikhail Zibinsky, Redwood City, CA (US);
RAPT THERAPEUTICS, INC., South San Francisco, CA (US);
Abstract
Disclosed herein are methods of synthesis of a trans isomeric form of a C—C chemokine receptor type 4 (CCR4) modulator, or a salt or ester thereof that comprise making a trans isomeric compound of formula (III) by reacting a compound of formula (I) with a compound of formula (II) in the presence of a carboxylic acid directed reducing agent, wherein the compound of formula (III) is in a predominantly trans isomerically pure form.