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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12428378 B1

PDFFull Text
Date of Patent:
Sep. 30, 2025

Filed:

Sep. 09, 2020

Methods and materials for increasing level of phosphorylated ampk protein

Applicant:

University of Pittsburgh—of the Commonwealth System of Higher Education, Pittsburgh, PA (US);

Inventors:

Beibei Chen, Sewickley, PA (US);

Toren Finkel, Pittsburgh, PA (US);

Yuan Liu, Sewickley, PA (US);

Assignee:

UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, Pittsburgh, PA (US);

Attorney:

Fish & Richardson P.C.

Primary Examiner:

Bruck Kifle

Int. Cl.
CPC ...
A61K 31/133 (2006.01); A61K 31/135 (2006.01); C07C 215/08 (2006.01); C07C 217/20 (2006.01); C07C 217/34 (2006.01); C07C 225/10 (2006.01); C07D 209/08 (2006.01); C07D 211/76 (2006.01); C07D 213/38 (2006.01); C07D 213/71 (2006.01); C07D 213/82 (2006.01); C07D 215/40 (2006.01); C07D 223/18 (2006.01); C07D 231/12 (2006.01); C07D 233/24 (2006.01); C07D 239/26 (2006.01); C07D 277/28 (2006.01); C07D 413/14 (2006.01); C07D 417/04 (2006.01);
U.S. Cl.
CPC ...
C07D 223/18 (2013.01); C07C 217/20 (2013.01); C07C 225/10 (2013.01); C07D 209/08 (2013.01); C07D 211/76 (2013.01); C07D 213/38 (2013.01); C07D 213/71 (2013.01); C07D 213/82 (2013.01); C07D 215/40 (2013.01); C07D 231/12 (2013.01); C07D 233/24 (2013.01); C07D 239/26 (2013.01); C07D 277/28 (2013.01); C07D 413/14 (2013.01); C07D 417/04 (2013.01); C07B 2200/05 (2013.01);
Abstract

This document provides methods and materials for increasing the level of phosphorylated AMPK. For example, compounds (e.g., organic compounds) having the ability to increase the level of phosphorylated AMPK within cells, formulations containing compounds having the ability to increase the level of phosphorylated AMPK within cells, methods for making compounds having the ability to increase the level of phosphorylated AMPK within cells, methods for making formulations containing compounds having the ability to increase the level of phosphorylated AMPK within cells, methods for increasing the level of phosphorylated AMPK within cells, and methods for treating mammals (e.g., humans) having a condition responsive to an increase in the level of phosphorylated AMPK are provided.

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