The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 30, 2025
Filed:
Nov. 05, 2021
California Institute of Technology, Pasadena, CA (US);
Yeda Research & Development Co. Ltd. AT the Weizmann Institute of Science, Rehovot, IL;
Dianne K Newman, Pasadena, CA (US);
Chelsey M Vandrisse, Pasadena, CA (US);
Rosalie Lipsh-Sokolik, Rehovot, IL;
Olga Khersonsky, Rehovot, IL;
Sarel J Fleishman, Rehovot, IL;
CALIFORNIA INSTITUTE OF TECHNOLOGY, Pasadena, CA (US);
YEDA RESEARCH & DEVELOPMENT CO LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE, Rehovot, IL;
Abstract
Provided herein are engineered pyocyanin demethylases having replacements in in positions A53, I73, A87, T91, M99, A129 and K141 of pyocyanin demethylase PodA of SEQ ID NO: 1 or a derivative thereof and related phenazine degrading agents, compositions, methods and systems, as well as a combined administration of one or more pyocyanin demethylases and antibiotics and/or antibiotics resulting in a synergic inhibition of viability of phenazine producing bacteria, and related phenazine degrading agents, compositions, methods and systems.