The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 30, 2025
Filed:
Jun. 01, 2020
Applicant:
Merck Sharp & Dohme Llc, Rahway, NJ (US);
Inventors:
Danqing Feng, Green Brook, NJ (US);
Songnian Lin, Holmdel, NJ (US);
Dmitri A. Pissarnitski, Scotch Plains, NJ (US);
Brenda Pipik, Edison, NJ (US);
Lin Yan, East Brunswick, NJ (US);
Yuping Zhu, Basking Ridge, NJ (US);
Assignee:
Merck Sharp & Dohme LLC, Rahway, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61K 38/28 (2006.01); A61K 47/54 (2017.01); A61K 47/65 (2017.01); A61P 3/10 (2006.01);
U.S. Cl.
CPC ...
A61K 38/28 (2013.01); A61K 47/549 (2017.08); A61K 47/65 (2017.08); A61P 3/10 (2018.01);
Abstract
Glucose-responsive insulin conjugates that contain one or more linear oligomer sugar cluster are provided. Such insulin conjugates that may display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose, even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule.