The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 30, 2025
Filed:
Mar. 31, 2015
Applicants:
The Johns Hopkins University, Baltimore, MD (US);
Biomed Valley Discoveries, Inc., Kansas City, MO (US);
Inventors:
Shibin Zhou, Owings Mills, MD (US);
Bert Vogelstein, Baltimore, MD (US);
Kenneth Kinzler, Baltimore, MD (US);
Kibem Kim, Lutherville, MD (US);
Saurabh Saha, Wellesley Hills, MA (US);
Assignee:
Biomed Valley Discoveries, Inc., Kansas City, MO (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/744 (2015.01); A61K 9/00 (2006.01); A61K 35/00 (2006.01); A61K 35/74 (2015.01); A61K 35/742 (2015.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
A61K 35/744 (2013.01); A61K 9/0019 (2013.01); A61K 35/74 (2013.01); A61K 35/742 (2013.01); A61K 39/3955 (2013.01); A61K 39/39558 (2013.01); C07K 16/2803 (2013.01); C07K 16/2818 (2013.01); A61K 2035/115 (2013.01); A61K 2039/505 (2013.01); A61K 2039/54 (2013.01); A61K 2039/545 (2013.01);
Abstract
The presently disclosed subject matter provides methods and kits for treating solid tumors in a subject by using a combination of anti-CTLA-4 and/or anti-PD-1 antibodies with at least one member of the group consisting of a bacterium, bacterial product, and an immunoregulatory entity. In particular embodiments, the bacteria are toxin-depleted, anaerobic bacteria, such as-NT.