The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 30, 2025

Filed:

Jul. 30, 2021
Applicants:

Bayer Aktiengesellschaft, Leverkusen, DE;

The Broad Institute, Inc., Cambridge, MA (US);

Inventors:

Stefan Nikolaus Gradl, Berlin, DE;

Manuel Ellermann, Berlin, DE;

Philip Lienau, Berlin, DE;

Charlotte Christine Kopitz, Falkensee, DE;

Martin Lange, Berlin, DE;

Adrian Tersteegen, Wuppertal, DE;

Detlev Sülzle, Berlin, DE;

Timothy A. Lewis, Cambridge, MA (US);

Heidi Greulich, Cambridge, MA (US);

Xiaoyun Wu, Cambridge, MA (US);

Assignees:

Bayer Aktiengesellschaft, Leverkusen, DE;

The Broad Institute, Inc., Cambridge, MA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/53 (2006.01); A61P 35/00 (2006.01); C07D 253/06 (2006.01); C07D 403/10 (2006.01); C07D 403/12 (2006.01);
U.S. Cl.
CPC ...
A61K 31/53 (2013.01); A61P 35/00 (2018.01); C07D 253/06 (2013.01); C07D 403/10 (2013.01); C07D 403/12 (2013.01);
Abstract

The present invention includes name compounds of general formula (I): (I) in which R, R, Rand Rare as defined herein, methods for their preparation, pharmaceutical compositions and combinations comprising said compounds, and their use for the treatment of hyperproliferative diseases.


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