The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 30, 2025
Filed:
Mar. 20, 2021
Aardvark Therapeutics, Inc., San Diego, CA (US);
Tien-Li Lee, San Diego, CA (US);
Aardvark Therapeutics, Inc., San Diego, CA (US);
Abstract
There is disclosed compositions and methods for treating and preventing Acute Respiratory Distress Syndrome (ARDS) including ARDS caused by viral respiratory disease of zoonotic origin such as coronaviruses. The present disclosure is based on a surprising discovery of significant efficacy in an acute lung injury model using intrapulmonary lipopolysaccharide (LPS) challenge in female CD-I mice. Based on these data, the test compound, denatonium acetate monohydrate (DA) (1) treats or prevents ARDS and, (2) treats severe acute respiratory syndrome (SARS) caused by a coronavirus. Therefore, the data achieved in these studies does have a story to tell and the story is that a DA pharmaceutical composition, administered orally, provided a method to treat or prevent ARDS and treat SARS. Preferably, the pharmaceutical composition for daily administration comprises DA delivering a daily total dose of from about 20 mg to about 2000 mg to a human adult.