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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12427106 B1

PDFFull Text
Date of Patent:
Sep. 30, 2025

Filed:

Jun. 19, 2019

Elastic sheet with function of re-activating endometrial basal layer in uterine cavity and forming method thereof

Applicant:

Yipurun (Shanghai) Biotechnology Co., Ltd., Shanghai, CN;

Inventors:

Peipei Xia, Shanghai, CN;

Zheng Wei, Shanghai, CN;

Wei Yan, Shanghai, CN;

Rui Yang, Shanghai, CN;

Assignee:

YIPURUN (SHANGHAI) BIOTECHNOLOGY CO., LTD., Shanghai, CN;

Attorney:

Dickinson Wright PLLC

Primary Examiner:

Chelsea E Stinson

Assistant Examiner:

Hamza A Darb

Int. Cl.
CPC ...
A61K 9/00 (2006.01); A61K 31/565 (2006.01); A61K 47/32 (2006.01); A61M 31/00 (2006.01); B29B 7/90 (2006.01); B29C 48/00 (2019.01); B29C 48/07 (2019.01); B29K 83/00 (2006.01); B29K 105/00 (2006.01); B29K 509/02 (2006.01); B29L 7/00 (2006.01);
U.S. Cl.
CPC ...
A61K 9/0039 (2013.01); A61K 31/565 (2013.01); A61K 47/32 (2013.01); A61M 31/00 (2013.01); B29B 7/90 (2013.01); B29C 48/022 (2019.02); B29C 48/07 (2019.02); A61M 2205/0216 (2013.01); A61M 2210/1433 (2013.01); B29K 2083/00 (2013.01); B29K 2105/0035 (2013.01); B29K 2509/02 (2013.01); B29L 2007/002 (2013.01);
Abstract

An elastic sheet for re-activating an endometrial basal layer in a uterine cavity comprises a silicone rubber and a drug, wherein the drug is encased inside the silicone rubber in the manner of a drug storage zone, or uniformly dispersed inside the silicone rubber, or carried by an outer surface of the silicone rubber as a coating, and the drug comprises an estrogen. A method for forming the elastic sheet with a drug in a matrix-type elastic sheet; or as a sustained release coating is provided. The estrogen is loaded on the silicone rubber, and thus the endometrial basal layer is continuously activated through drug stimulation, allowing for the endometrial basal layer to re-proliferate the functional layers, thereby restoring the normal endometrial structure and completely preventing adhesions.

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