The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 23, 2025
Filed:
Apr. 13, 2022
Applicant:
Biomadison, Inc., Del Mar, CA (US);
Inventors:
Dhammika Atapattu, Madison, WI (US);
Ward C. Tucker, Monona, WI (US);
Assignee:
BIOMADISON, INC., Del Mar, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/542 (2006.01); C07K 14/00 (2006.01); C12N 15/85 (2006.01); G01N 33/58 (2006.01);
U.S. Cl.
CPC ...
G01N 33/542 (2013.01); C07K 14/00 (2013.01); C12N 15/85 (2013.01); G01N 33/582 (2013.01); G01N 2333/33 (2013.01);
Abstract
Compositions and methods for characterization binding proteins are described that include use of a reporting construct that incorporates a bait region that interacts with the binding protein and a reporter that is susceptible to degradation in the reporter's local environment. Complex formation between the bait region and the binding protein provides protection of the susceptible reporter from degradation. Such a reporting construct can be utilized to identify cells expressing a binding protein when the susceptible reporter is susceptible to degradation in cytosol.