The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 23, 2025
Filed:
Feb. 23, 2021
Applicant:
Roche Innovation Center Copenhagen A/s, Horsholm, DK;
Inventors:
Jesper Worm, Copenhagen, DK;
Lukasz Kielpinski, Horsholm, DK;
Assignee:
Roche Innovation Center Copenhagen A/S, Horsholm, DK;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/6883 (2018.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
C12Q 1/6883 (2013.01); C12N 15/113 (2013.01); C12N 2310/11 (2013.01); C12N 2310/3231 (2013.01); C12Q 2600/158 (2013.01);
Abstract
The invention relates to the field of secondary markers for microRNA activity, and in particular the invention relates to the identification of Serpine1 as a mRNA which is repressed by microRNA-134 in neuronal cells, and the use of Serpine1 mRNA or protein as a biomarker for microRNA-134 modulation, such as a biomarker for antisense oligonucleotide inhibitors of microRNA-134.