The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 23, 2025
Filed:
Jul. 16, 2019
Applicant:
Children's Hospital Medical Center, Cincinnati, OH (US);
Inventors:
Takanori Takebe, Cincinnati, OH (US);
Hiroyuki Koike, Tokyo, JP;
Assignee:
Children's Hospital Medical Center, Cincinnati, OH (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); A61K 35/28 (2015.01); A61K 35/39 (2015.01); A61K 35/407 (2015.01); A61K 35/413 (2015.01); A61K 35/44 (2015.01); A61K 35/545 (2015.01); C12N 5/071 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0677 (2013.01); A61K 35/28 (2013.01); A61K 35/39 (2013.01); A61K 35/407 (2013.01); A61K 35/413 (2013.01); A61K 35/44 (2013.01); A61K 35/545 (2013.01); C12N 5/0671 (2013.01); C12N 5/0697 (2013.01); C12N 2501/115 (2013.01); C12N 2501/155 (2013.01); C12N 2501/415 (2013.01); C12N 2501/727 (2013.01); C12N 2502/14 (2013.01); C12N 2502/22 (2013.01); C12N 2506/45 (2013.01); C12N 2513/00 (2013.01); C12N 2533/90 (2013.01);
Abstract
Disclosed herein are hepato-biliary-pancreatic organoid ('HBPO' or “HBP organoid”) compositions, and methods of making and using hepato-biliary-pancreatic organoid compositions. The disclosed compositions may have two or more functions selected from hepatic tissue function, biliary tissue function, exocrine pancreatic function, and endocrine pancreatic tissue function. Methods of treating individuals using the hepato-biliary-pancreatic organoid compositions is also disclosed.