The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 23, 2025

Filed:

Sep. 21, 2018
Applicant:

Korea Research Institute of Bioscience and Biotechnology, Daejeon, KR;

Inventors:

Yee Sook Cho, Daejeon, KR;

Han-Seop Kim, Daejeon, KR;

Binna Seol, Daejeon, KR;

In Pyo Choi, Daejeon, KR;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/0783 (2010.01); A61K 40/15 (2025.01); A61K 40/42 (2025.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0646 (2013.01); A61K 40/15 (2025.01); A61K 40/42 (2025.01); A61P 35/00 (2018.01); C12N 5/0638 (2013.01); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05); A61K 2239/50 (2023.05); C12N 2501/2307 (2013.01); C12N 2501/2315 (2013.01); C12N 2501/602 (2013.01); C12N 2501/603 (2013.01); C12N 2501/604 (2013.01); C12N 2501/606 (2013.01); C12N 2501/727 (2013.01);
Abstract

The present invention relates to a method for producing natural killer cells using direct reprogramming, natural killer cells produced thereby, a biomarker specific to the natural killer cells, a cell therapeutic agent comprising the natural killer cells, a composition for treatment and prevention of cancer, a cryopreservation cell vial for storing the natural killer cells, and a medium kit for inducing the direct reprogramming. Exhibiting excellent proliferative potential and cancer cell killing potential, the natural killer cells produced by the production method can be effectively utilized for mass production and in a composition for treatment and prevention of cancer.


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