The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 23, 2025
Filed:
Mar. 10, 2021
Applicant:
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Inventors:
Dennis E. Discher, Philadelphia, PA (US);
Kyle R. Spinler, La Jolla, CA (US);
Cory Alvey, Philadelphia, PA (US);
Assignee:
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/0786 (2010.01); A61K 35/12 (2015.01); A61K 35/28 (2015.01); A61K 40/10 (2025.01); A61K 40/17 (2025.01); A61K 40/24 (2025.01); A61K 40/42 (2025.01); A61K 47/68 (2017.01); A61K 49/00 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0645 (2013.01); A61K 35/28 (2013.01); A61K 40/10 (2025.01); A61K 40/17 (2025.01); A61K 40/24 (2025.01); A61K 40/4202 (2025.01); A61K 40/4204 (2025.01); A61K 40/4257 (2025.01); A61K 47/6851 (2017.08); A61K 49/0041 (2013.01); A61K 49/0097 (2013.01); A61K 2035/124 (2013.01); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05); A61K 2239/55 (2023.05); C12N 2510/00 (2013.01);
Abstract
The present invention relates to compositions and methods that provide novel therapies in cancer. The invention includes a phagocytic cell modified with a repressor of signal regulatory protein-alpha (SIRPα) and bound to a targeting antibody to enhance phagocytic activity of the phagocytic cell toward tumor tissue. Methods of enhancing phagocytic activity and treating a tumor are also included.