The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 23, 2025

Filed:

Apr. 02, 2020
Applicant:

Vertex Pharmaceuticals Incorporated, Boston, MA (US);

Inventors:

Alexander Russell Abela, Escondido, CA (US);

Sunny Abraham, San Diego, CA (US);

Corey Don Anderson, Brighton, MA (US);

Vijayalaksmi Arumugam, San Marcos, CA (US);

Jaclyn Chau, San Diego, CA (US);

Jeremy Clemens, San Diego, CA (US);

Thomas Cleveland, San Marcos, CA (US);

Timothy A Dwight, Quincy, MA (US);

Bryan A. Frieman, La Jolla, CA (US);

Peter Grootenhuis, Del Mar, CA (US);

Sara Sabina Hadida Ruah, La Jolla, CA (US);

Yoshihiro Ishihara, San Diego, CA (US);

Paul Krenitsky, San Francisco, CA (US);

Jason Mccartney, Cardiff by the Sea, CA (US);

Vito Melillo, Escondido, CA (US);

Mark Thomas Miller, Rancho Santa Fe, CA (US);

Alina Silina, Needham, MA (US);

Johnny Uy, San Diego, CA (US);

Jinglan Zhou, San Diego, CA (US);

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 515/08 (2006.01); C07D 215/233 (2006.01); C07D 239/69 (2006.01); C07D 405/12 (2006.01);
U.S. Cl.
CPC ...
C07D 515/08 (2013.01); C07D 215/233 (2013.01); C07D 239/69 (2013.01); C07D 405/12 (2013.01); C07B 2200/05 (2013.01);
Abstract

Compound (I), deuterated derivatives, and pharmaceutically acceptable salts of any of the foregoing are disclosed. Methods of treating cystic fibrosis using these compounds are also disclosed.


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