The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 23, 2025
Filed:
Nov. 08, 2023
Vertex Pharmaceuticals Incorporated, Boston, MA (US);
Jun Myun Ahn, Waltham, MA (US);
Samantha Angle, Cambridge, MA (US);
Michael Aaron Brodney, Newton, MA (US);
Jingrong Cao, Newton, MA (US);
John E. Cochran, Marshfield, MA (US);
Jon H. Come, Cambridge, MA (US);
Leslie A. Dakin, Framingham, MA (US);
Elena Dolgikh, Boston, MA (US);
Brad D. Maxwell, Holliston, MA (US);
Suganthini S. Nanthakumar, Newton, MA (US);
Hardwin O′dowd, Cambridge, MA (US);
Jessica Howard Olsen, Jamaica Plain, MA (US);
Timothy J. Senter, Arlington, MA (US);
Akira Joseph Shimizu, Framingham, MA (US);
Steven David Stone, Quincy, MA (US);
Haoxuan Wang, Somerville, MA (US);
Vertex Pharmaceuticals Incorporated, Boston, MA (US);
Abstract
The disclosure provides at least one entity chosen from compounds of Formula I, a tautomer thereof, a deuterated derivative of that compound or tautomer, and a pharmaceutically acceptable salt of any of the foregoing, compositions comprising the same, and methods of using the same, including uses in treating APOL1-mediated diseases, including pancreatic cancer, focal segmental glomerulosclerosis (FSGS), and/or non-diabetic kidney disease (NDKD).