The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 23, 2025
Filed:
Jan. 09, 2020
Applicant:
Eisai R&d Management Co., Ltd., Tokyo, JP;
Inventors:
Francis G. Fang, Andover, MA (US);
Branko Mitasev, North Reading, MA (US);
Jiong Yang, Andover, MA (US);
Assignee:
Eisai R&D Management Co., Ltd., Tokyo, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); C07C 229/36 (2006.01); C07C 247/10 (2006.01); C07C 311/18 (2006.01); C07D 203/12 (2006.01); C07D 205/04 (2006.01); C07D 307/33 (2006.01); C07D 317/28 (2006.01); C07D 403/06 (2006.01); C07D 405/14 (2006.01); C07D 491/147 (2006.01);
U.S. Cl.
CPC ...
C07D 491/147 (2013.01); C07C 311/18 (2013.01); C07D 307/33 (2013.01); C07D 403/06 (2013.01); C07D 405/14 (2013.01); C07D 487/04 (2013.01);
Abstract
A method for the synthesis of diazabicyclo[6.2.0]decane compounds is provided. The synthesis proceeds by stereoselective synthesis of a chiral lactone followed by azetidine formation via a series of chemoselective reactions. Bicyclization results with the formation of diazobicyclo[6.2.0]decane related compounds.