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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12421220 B1

PDFFull Text
Date of Patent:
Sep. 23, 2025

Filed:

Dec. 06, 2024

Bicyclic-substituted glutarimide cereblon binders

Applicant:

C4 Therapeutics, Inc., Watertown, MA (US);

Inventors:

Christopher G. Nasveschuk, Stoneham, MA (US);

Kiel Lazarski, Boston, MA (US);

Yanke Liang, Belmont, MA (US);

Alexander W. Hird, Belmont, MA (US);

Ning Yin, Lexington, MA (US);

Andrew Charles Good, Bideford, GB;

Hongwei Huang, Bedford, MA (US);

Scott Joseph Eron, Waltham, MA (US);

Gesine Kerstin Veits, Somerville, MA (US);

Assignee:

C4 THERAPEUTICS, INC., Watertown, MA (US);

Attorney:

Knowles Intellectual Property Strategies, LLC

Primary Examiner:

Kahsay Habte

Int. Cl.
CPC ...
C07D 413/04 (2006.01); A61K 31/4709 (2006.01); A61K 31/496 (2006.01); A61K 31/5377 (2006.01); A61K 31/5383 (2006.01); A61K 31/5415 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01); C07D 487/10 (2006.01); C07D 498/04 (2006.01);
U.S. Cl.
CPC ...
C07D 413/04 (2013.01); A61K 31/4709 (2013.01); A61K 31/496 (2013.01); A61K 31/5377 (2013.01); A61K 31/5383 (2013.01); A61K 31/5415 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 487/10 (2013.01); C07D 498/04 (2013.01);
Abstract

This invention provides Degron compounds which bind to cereblon which is a component of the E3 ubiquitin ligase. The Degrons provided herein can be used to modulate the activity of cereblon either alone or as covalently linked to a Tail. Alternatively, the Degron can be linked to a Targeting Ligand which binds to a Target Protein for protein degradation.

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