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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12420262 B1

PDFFull Text
Date of Patent:
Sep. 23, 2025

Filed:

Nov. 25, 2020

Chromatographic column having stationary phase thickness gradient

Applicant:

The Regents of the University of Michigan, Ann Arbor, MI (US);

Inventors:

Xudong Fan, Saline, MI (US);

Hongbo Zhu, Johnson City, TN (US);

Jinyan She, Ann Arbor, MI (US);

Maxwell Wei-Hao Li, Troy, MI (US);

Katsuo Kurabayashi, Ann Arbor, MI (US);

Assignee:

The Regents of The University of Michigan, Ann Arbor, MI (US);

Attorney:

Harness, Dickey & Pierce, P.L.C.

Primary Examiner:

Jennifer Wecker

Assistant Examiner:

Oyeleye Alexander Alabi

Int. Cl.
CPC ...
B01L 3/00 (2006.01); B01D 15/08 (2006.01); B01F 33/302 (2022.01); B01F 33/3033 (2022.01); B01J 20/285 (2006.01); B01J 20/287 (2006.01); B01J 20/32 (2006.01); B01L 7/00 (2006.01); B01L 9/00 (2006.01); B65G 47/80 (2006.01); B82Y 20/00 (2011.01); B82Y 30/00 (2011.01); B82Y 40/00 (2011.01); C12M 1/34 (2006.01); C12M 3/06 (2006.01); C12N 1/14 (2006.01); C12N 1/20 (2006.01); C12Q 1/02 (2006.01); C12Q 1/6806 (2018.01); C12Q 1/6844 (2018.01); C12Q 1/6848 (2018.01); C12Q 1/686 (2018.01); G01N 15/10 (2024.01); G01N 15/14 (2024.01); G01N 15/1433 (2024.01); G01N 21/29 (2006.01); G01N 21/65 (2006.01); G01N 30/02 (2006.01); G01N 30/60 (2006.01); G01N 30/72 (2006.01); G01N 33/543 (2006.01); G01N 33/557 (2006.01); G01N 33/574 (2006.01); G01N 33/58 (2006.01);
U.S. Cl.
CPC ...
B01J 20/287 (2013.01); B01J 20/285 (2013.01); B01J 20/3282 (2013.01); G01N 30/6065 (2013.01); G01N 30/6078 (2013.01); G01N 2030/025 (2013.01);
Abstract

A gas chromatography device for peak focusing of one or more target analytes is provided that include a chromatographic column with an inlet and an outlet. A stationary phase is deposited inside the chromatographic column and has a positive thickness gradient. The stationary phase extends from the inlet to the outlet and has a first thickness at the inlet of the chromatographic column and a second thickness at the outlet of the chromatographic column. The second thickness is at least about 10% greater than the first thickness. Methods of peak focusing in a gas chromatography device, method of verifying peak focusing in a gas chromatography device and creating a gas chromatography device having a chromatographic column with a positive thickness gradient are also provided.

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