The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 23, 2025

Filed:

Oct. 18, 2017
Applicants:

University of Pittsburgh-of the Commonwealth System of Higher Education, Pittsburgh, PA (US);

Upmc, Pittsburgh, PA (US);

Universidad DE Santiago DE Chile, Santiago, CL;

Inventors:

William R. Wagner, Gibsonia, PA (US);

Sachin Shankar Velankar, Pittsburgh, PA (US);

Sang Ho Ye, Pittsburgh, PA (US);

Edith Tzeng, Presto, PA (US);

Luka Pocivavsek, Pittsburgh, PA (US);

Enrique Cerda, Santiago, CL;

Assignees:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
B32B 7/022 (2019.01); A61F 2/06 (2013.01); A61L 27/26 (2006.01); A61L 29/04 (2006.01); A61L 33/06 (2006.01); B32B 1/08 (2006.01); B32B 3/28 (2006.01); B32B 37/10 (2006.01); B32B 37/16 (2006.01); B32B 38/00 (2006.01); B81C 1/00 (2006.01);
U.S. Cl.
CPC ...
A61L 33/062 (2013.01); A61F 2/06 (2013.01); A61L 27/26 (2013.01); A61L 29/049 (2013.01); B32B 1/08 (2013.01); B32B 3/28 (2013.01); B32B 7/022 (2019.01); B32B 37/1054 (2013.01); B81C 1/00206 (2013.01); A61F 2210/0076 (2013.01); A61F 2240/001 (2013.01); A61F 2250/0018 (2013.01); A61L 2430/20 (2013.01); B32B 37/16 (2013.01); B32B 2038/0028 (2013.01); B32B 2309/16 (2013.01); B32B 2535/00 (2013.01); B81C 2201/0156 (2013.01); B81C 2201/0163 (2013.01);
Abstract

The present invention relates to substrates and composites having dynamic, reversible micron-level luminal surface deformation including texture or geometric instabilities, e.g., surface wrinkling and folding. The surface deformation and its reversal to the original surface form or to another, different surface form, is effective to reduce or prevent surface fouling and, more particularly, in certain applications, to reduce or prevent unwanted platelet adhesion and thrombus formation. The substrates and composites include a wide variety of designs and, more particularly, biomedical-related designs, such as, synthetic vascular graft or patch designs.


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