The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 23, 2025

Filed:

Sep. 30, 2019
Applicants:

Johannes Gutenberg-universität Mainz, Mainz, DE;

Biontech SE, Mainz, DE;

Inventors:

Matthias Barz, Worms, DE;

Benjamin Weber, Mainz, DE;

Heinrich Haas, Mainz, DE;

Philipp Heller, Mainz, DE;

Sara Nogueira, Mainz, DE;

Anne Schlegel, Mainz, DE;

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/69 (2017.01); A61K 9/127 (2025.01); A61K 47/54 (2017.01); A61K 48/00 (2006.01); C12N 15/85 (2006.01); C12N 15/88 (2006.01); A61K 9/51 (2006.01); A61K 47/18 (2017.01); A61K 47/24 (2006.01); A61K 47/28 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6935 (2017.08); A61K 47/543 (2017.08); A61K 47/6911 (2017.08); A61K 48/0041 (2013.01); C12N 15/85 (2013.01); C12N 15/88 (2013.01); A61K 9/127 (2013.01); A61K 9/5146 (2013.01); A61K 47/18 (2013.01); A61K 47/24 (2013.01); A61K 47/28 (2013.01);
Abstract

The present disclosure relates to RNA particles for delivery of RNA to target tissues after administration, in particular after parenteral administration such as intravenous, intramuscular, subcutaneous or intratumoral administration, and compositions comprising such RNA particles. The RNA particles in one embodiment comprise single-stranded RNA such as mRNA which encodes a peptide or protein of interest, such as a pharmaceutically active peptide or protein. The RNA is taken up by cells of a target tissue and the RNA is translated into the encoded peptide or protein, which may exhibit its physiological activity.


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