The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 23, 2025
Filed:
Mar. 20, 2023
Dna Twopointo, Inc., Newark, CA (US);
The General Hospital Corporation, Boston, MA (US);
Yifang Shui, Boston, MA (US);
Jeremy Minshull, Los Altos, CA (US);
Maggie Lee, San Jose, CA (US);
Feng Shi, Winchester, MA (US);
Mark Cobbold, Winchester, MA (US);
DNA Twopointo, Inc., Newark, CA (US);
The General Hospital Corporation, Boston, MA (US);
Abstract
Modified immune cells are provided, the modified immune cells expressing a heterologous polynucleotide comprising a nucleotide sequence encoding a function (e.g., at least one of persistence, proliferation, or cytotoxicity) booster, e.g., an apoptosis inhibitor. In one aspect, the modified T cells further comprise a chimeric antigen receptor. Methods, kits, and components for making and using the modified immune cells are also provided.