The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 23, 2025
Filed:
Jul. 03, 2019
Applicant:
Yale University, New Haven, CT (US);
Inventors:
Stephen M. Strittmatter, Durham, CT (US);
Erik Christian Gunther, Branford, CT (US);
Levi M. Smith, Branford, CT (US);
Assignee:
YALE UNIVERSITY, New Haven, CT (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/795 (2006.01); A61K 31/155 (2006.01); A61K 31/195 (2006.01); A61K 31/198 (2006.01); A61K 31/64 (2006.01); A61K 31/78 (2006.01); A61K 31/785 (2006.01); A61K 31/787 (2006.01); A61K 31/80 (2006.01); A61K 36/16 (2006.01); A61K 38/26 (2006.01); A61K 38/28 (2006.01); A61K 45/06 (2006.01); A61P 25/28 (2006.01);
U.S. Cl.
CPC ...
A61K 31/795 (2013.01); A61K 31/155 (2013.01); A61K 31/195 (2013.01); A61K 31/198 (2013.01); A61K 31/64 (2013.01); A61K 31/78 (2013.01); A61K 31/785 (2013.01); A61K 31/787 (2013.01); A61K 31/80 (2013.01); A61K 36/16 (2013.01); A61K 38/26 (2013.01); A61K 38/28 (2013.01); A61K 45/06 (2013.01); A61P 25/28 (2018.01);
Abstract
The disclosure provides polymeric compounds that inhibit binding of an amyloid-β-oligomer to cellular prion protein, methods for identifying such compounds, and their therapeutic use. In particular, the present disclosure provides a collection of anionic polymers and methods of using these compounds to treat amyloid-related disorders, e.g., Alzheimer's disease.