The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 23, 2025
Filed:
Dec. 10, 2021
Institut DE Cardiologie DE Montreal, Montréal, CA;
Affina Biotechnologies, Inc., Valhalla, NY (US);
Alan Berezov, White Plains, NY (US);
Alexander Vinitsky, New York, NY (US);
Steve Poirier, Montréal, CA;
Gaétan Mayer, Montréal, CA;
INSTITUT DE CARDIOLOGIE DE MONTREAL, Montréal, CA;
AFFINA BIOTECHNOLOGIES, INC., Valhalla, NY (US);
Abstract
The present invention relates to compounds of Table 1, which are encompassed by Formula I and/or Formula II, Ill, IV, V, or VI, and pharmaceutically acceptable salts, solvates or compositions thereof. Compounds of Table 1 are PCSK9 interacting small molecules that modulate PCSK9 activity and significantly increase low density lipoprotein receptor expression and activity, lower total circulating cholesterol and are useful for treating and delaying the onset of diseases that are associated with elevated cholesterol.