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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12419880 B1

PDFFull Text
Date of Patent:
Sep. 23, 2025

Filed:

Jun. 18, 2021

Companion diagnostic tool for mutant p53 reactivating compounds

Applicant:

Pmv Pharmaceuticals, Inc., Cranbury, NJ (US);

Inventor:

Melissa Dumble, Watchung, NJ (US);

Assignee:

PMV PHARMACEUTICALS, INC., Princeton, NJ (US);

Attorney:

WILSON SONSINI GOODRICH & ROSATI

Primary Examiner:

Amanda L Aguirre

Assistant Examiner:

Chris E Simmons

Int. Cl.
CPC ...
A61K 31/454 (2006.01); A61K 31/404 (2006.01); A61K 31/4045 (2006.01); A61K 31/438 (2006.01); A61K 31/4439 (2006.01); A61K 31/4545 (2006.01); A61K 31/496 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61K 31/538 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/454 (2013.01); A61K 31/404 (2013.01); A61K 31/4045 (2013.01); A61K 31/438 (2013.01); A61K 31/4439 (2013.01); A61K 31/4545 (2013.01); A61K 31/496 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 31/538 (2013.01); A61P 35/00 (2018.01);
Abstract

Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods that restore DNA binding affinity of p53 mutants. The compounds of the present disclosure can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

Find Patent Forward Citations

Dumble, Melissa. (2025). Companion diagnostic tool for mutant p53 reactivating compounds (U.S. Patent No. 12419880). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12419880

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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