The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 23, 2025
Filed:
Apr. 18, 2022
Applicant:
Trustees of Dartmouth College, Hanover, NH (US);
Inventors:
Ta Yuan Chang, Etna, NH (US);
Catherine C.y. Chang, Etna, NH (US);
Haibo Li, Hanover, NH (US);
Adrianna De La Torre, Lyme, NH (US);
Thao N. Huynh, Concord, NH (US);
Assignee:
Trustees of Dartmouth College, Hanover, NH (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/167 (2006.01); A61K 9/127 (2006.01); A61P 25/28 (2006.01);
U.S. Cl.
CPC ...
A61K 31/167 (2013.01); A61K 9/127 (2013.01); A61P 25/28 (2018.01);
Abstract
The present invention features compositions and methods for preventing or treating neuroinflammation, amyloidopathy or tauopathy by inhibiting Acyl-CoA:Cholesterol Acyltransferase activity, in particular with brain-permeable inhibitors encapsulated in a stealth liposome-based nanoparticle. Stealth liposome-based nanoparticles for reducing or attenuating amyloidopathy or tauopathy are also provided.