The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 16, 2025
Filed:
Jun. 11, 2018
Singapore Health Services Pte. Ltd., Singapore, SG;
Salvatore Albani, Singapore, SG;
Jing Yao Leong, Singapore, SG;
SINGAPORE HEALTH SERVICES PTE. LTD., Singapore, SG;
Abstract
Methods and kits for evaluating a clinical outcome of an autoimmune disease, specifically disease flare e.g. if the subject stops taking the biologic disease modifying anti-rheumatic drug (DMARD), by comparing biomarkers of CD45RA, TNF-alpha and/or CXCR5 from CD3CD4T cell population are disclosed. In a specific embodiment, the ratio of first subset of CD3CD4CD45RA−TNFA(memory) T cells to a second subset comprising CD3CD4CD45RATNFA(naïve) T cell is determined, wherein an increase in the ratio indicates a disease flare state of juvenile idiopathic arthritis (JIA). In another embodiment, enrichment of CD45RA−CR5subset among the T cell population indicates likelihood of flare state in JIA via memory persistence enhancement through B cell interaction. In other embodiments, additional markers including IL-6, CCR6, CD152 and PD1 are also determined, and the enrichment of CD45RA-TNFAIL-6subset among the T cell population indicates a likelihood of amplification of the autoimmune disease.