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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12416029 B1

PDFFull Text
Date of Patent:
Sep. 16, 2025

Filed:

Oct. 07, 2021

Compositions and methods for making benzylisoquinoline alkaloids, morphinan alkaloids, thebaine, and derivatives thereof

Applicant:

Antheia, Inc., Menlo Park, CA (US);

Inventors:

Peter James Facchini, Calgary, CA;

Xue Chen, Calgary, CA;

Jeffrey C. Colbeck, Davis, CA (US);

Joseph E. Tucker, Strathmore, CA;

Assignee:

Antheia Inc., Menlo Park, CA (US);

Attorney:

Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.

Primary Examiner:

Robert B Mondesi

Assistant Examiner:

Mohammad Y Meah

Int. Cl.
CPC ...
C12N 9/70 (2006.01); C12N 9/88 (2006.01); C12P 17/18 (2006.01); C12N 15/70 (2006.01); C12P 13/22 (2006.01); C12P 17/12 (2006.01);
U.S. Cl.
CPC ...
C12P 17/182 (2013.01); C12N 9/88 (2013.01); C12N 15/70 (2013.01); C12P 13/22 (2013.01); C12P 17/12 (2013.01); C12Y 114/16002 (2013.01); C12Y 201/01128 (2013.01);
Abstract

Disclosed herein are methods that may be used for the synthesis of benzylisoquinoline alkaloids ('BIAs') such as alkaloid morphinan. The methods disclosed can be used to produce thebaine, oripavine, codeine, morphine, oxycodone, hydrocodone, oxymorphone, hydromorphone, naltrexone, naloxone, hydroxycodeinone, neopinone, and/or buprenorphine. Compositions and organisms useful for the synthesis of BIAs, including thebaine synthesis polypeptides, purine permeases, and polynucleotides encoding the same, are provided.

Find Patent Forward Citations

Facchini, Peter. (2025). Compositions and methods for making benzylisoquinoline alkaloids, morphinan alkaloids, thebaine, and derivatives thereof (U.S. Patent No. 12416029). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12416029

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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