The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 16, 2025

Filed:

Nov. 03, 2017
Applicants:

Cell Microsystems, Inc., Research Triangle Park, NC (US);

The University of North Carolina AT Chapel Hill, Chapel Hill, NC (US);

Inventors:

Steven C. Gebhart, Durham, NC (US);

Robert W. Mcclellan, Apex, NC (US);

Nicholas C. Trotta, Durham, NC (US);

Nancy L. Allbritton, Chapel Hill, NC (US);

Peter Joseph Attayek, Durham, NC (US);

Paul Michael Armistead, Durham, NC (US);

Assignees:

Cell Microsystems, Inc, Research Triangle Park, NC (US);

The University of North Carolina at Chapel Hill, Chapel Hill, NC (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12M 1/36 (2006.01); C12M 1/00 (2006.01); C12M 1/32 (2006.01); C12M 1/34 (2006.01); C40B 30/06 (2006.01); C40B 50/06 (2006.01); C40B 60/14 (2006.01); G01N 15/06 (2006.01); G01N 15/1433 (2024.01); G01N 15/1434 (2024.01); G01N 21/64 (2006.01); C40B 60/12 (2006.01); G01N 15/10 (2006.01);
U.S. Cl.
CPC ...
C12M 41/48 (2013.01); C12M 23/12 (2013.01); C12M 41/36 (2013.01); C12M 47/04 (2013.01); C40B 30/06 (2013.01); C40B 50/06 (2013.01); C40B 60/14 (2013.01); G01N 15/0612 (2013.01); G01N 15/1433 (2024.01); G01N 15/1434 (2013.01); G01N 21/6408 (2013.01); G01N 21/6428 (2013.01); G01N 21/6452 (2013.01); G01N 21/6458 (2013.01); B01J 2219/00308 (2013.01); B01J 2219/00317 (2013.01); B01J 2219/00743 (2013.01); C40B 60/12 (2013.01); G01N 2015/1006 (2013.01); G01N 2015/1447 (2013.01); G01N 2015/1452 (2013.01); G01N 2021/6439 (2013.01); G01N 2201/129 (2013.01);
Abstract

Embodiments of the disclosed subject matter provide an automated method and system to isolate and collect cells using computerized analysis of images of cells and their surroundings obtained from a digital imaging device or system. Embodiments of the disclosed subject matter make use of a 'microwell array,' which can comprise a formed, elastomeric grid of indentations or “wells.” Many, most, or all of the wells in a microwell array can contain a releasable, microfabricated element, which can be referred to as a “raft.” Embodiments of the disclosed subject matter provide a system and method for cell collection that includes computerized identification and collection of rafts with isolated single cells or a specific group or groups of cells, eliminating the need for continuous human identification and selection.


Find Patent Forward Citations

Loading…