The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 16, 2025
Filed:
Oct. 08, 2019
Boehringer Ingelheim International Gmbh, Ingelheim am Rhein, DE;
Jonathan Coffman, Gaithersbury, CA (US);
Scott Godfrey, Pleasanton, CA (US);
Lisa Sawicki, Brisbane, CA (US);
Boehringer Ingelheim International GmbH, Ingelheim am Rhein, DE;
Abstract
The present invention provides improved bioprocessing systems and methods for cell culture using the improved bioreactors, e.g., batch-fed or perfusion bioreactor cell culture systems for production of monoclonal or bi-specific antibodies, which are modified to include one or more membrane gas transfer modules in place of a sparger- or microsparger-based aeration systems to better regulate the levels of critical gases in a bioreactor cell culture, e.g., the dissolved levels of Oand CO, even at high cell densities, without subjecting the cells to bubble-burst associated cell death.