The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 16, 2025
Filed:
Dec. 04, 2020
Applicant:
Aarhus Universitet, Aarhus C, DK;
Inventors:
Thomas Bjørnskov Poulsen, Højbjerg, DK;
Per Hjerrild, Aarhus C, DK;
Kristian Mark Jacobsen, Harlev J, DK;
Thomas Tørring, Højbjerg, DK;
Assignee:
Aarhus Universitet, Aarhus C, DK;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 273/00 (2006.01); C07D 413/06 (2006.01); C07D 498/04 (2006.01);
U.S. Cl.
CPC ...
C07D 273/00 (2013.01); C07D 413/06 (2013.01); C07D 498/04 (2013.01);
Abstract
The present disclosure provides macrocyclic compounds comprising a 4-amido-2,4-pentadienoate (APD) moiety. The compounds exhibit toxicity that is selective to the hypoxic micro-environments often found in cancerous tissues. The disclosed compounds are therefore suitable for treatment of hypoxic cancer cells.