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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12415779 B1

PDFFull Text
Date of Patent:
Sep. 16, 2025

Filed:

Oct. 11, 2022

Processes of making 3-fluoro-5-(((1s,2ar)-1,3,3,4,4-pentafluoro-2a-hydroxy-2,2a,3,4-tetrahydro-1h-cyclopenta[cd]inden-7-yl)oxy)-benzonitrile and polymorphs thereof

Applicant:

Nikang Therapeutics, Inc., Wilmington, DE (US);

Inventors:

Charles M. Cook, Wilmington, DE (US);

Jiping Fu, Danville, CA (US);

Yigang He, Newark, DE (US);

Yan Lou, Pleasanton, CA (US);

Rongzhen Chen, Jiangsu, CN;

Yan Dong, Jiangsu, CN;

Assignee:

NIKANG THERAPEUTICS, INC., Wilmington, DE (US);

Attorney:

Squire Patton Boggs (US) LLP

Primary Examiner:

Adam C Milligan

Assistant Examiner:

Jason undefined Nolan

Int. Cl.
CPC ...
A61K 9/20 (2006.01); A61K 9/00 (2006.01); A61K 9/06 (2006.01); A61K 9/08 (2006.01); A61K 9/48 (2006.01); A61K 47/10 (2017.01); A61K 47/12 (2006.01); A61K 47/14 (2017.01); A61K 47/26 (2006.01); A61K 47/38 (2006.01); C07C 253/30 (2006.01); C07C 253/34 (2006.01); C07C 255/54 (2006.01);
U.S. Cl.
CPC ...
C07C 255/54 (2013.01); A61K 9/0019 (2013.01); A61K 9/0043 (2013.01); A61K 9/0048 (2013.01); A61K 9/0078 (2013.01); A61K 9/06 (2013.01); A61K 9/08 (2013.01); A61K 9/2013 (2013.01); A61K 9/2018 (2013.01); A61K 9/2054 (2013.01); A61K 9/2059 (2013.01); A61K 9/4825 (2013.01); A61K 9/4858 (2013.01); A61K 47/10 (2013.01); A61K 47/12 (2013.01); A61K 47/14 (2013.01); A61K 47/26 (2013.01); A61K 47/38 (2013.01); C07C 253/30 (2013.01); C07C 253/34 (2013.01); C07B 2200/13 (2013.01);
Abstract

The present disclosure provides certain processes of making 3-fluoro-5-(((1S,2aR)-1,3,3,4,4-pentafluoro-2a-hydroxy-2,2a,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)oxy)-benzonitrile (Compound 1) and certain polymorphs thereof. Also provided are pharmaceutical compositions comprising a crystalline polymorph form of Compound 1 and processes for preparing such polymorph forms.

Find Patent Forward Citations

Cook, Charles. (2025). Processes of making 3-fluoro-5-(((1s,2ar)-1,3,3,4,4-pentafluoro-2a-hydroxy-2,2a,3,4-tetrahydro-1h-cyclopenta[cd]inden-7-yl)oxy)-benzonitrile and polymorphs thereof (U.S. Patent No. 12415779). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12415779

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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