The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 16, 2025
Filed:
Jan. 08, 2019
Applicants:
President and Fellows of Harvard College, Cambridge, MA (US);
The Regents of the University of California, Oakland, CA (US);
Inventors:
Samir Mitragotri, Lexington, MA (US);
Michael Andrew Evans, Cambridge, MA (US);
Charles Wyatt Shields, Iv, Longmont, CO (US);
Assignees:
PRESIDENT AND FELLOWS OF HARVARD COLLEGE, Cambridge, MA (US);
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/69 (2017.01); A61K 9/51 (2006.01); A61K 38/20 (2006.01); A61K 38/21 (2006.01); A61K 40/17 (2025.01); A61K 40/24 (2025.01); A61K 40/42 (2025.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6901 (2017.08); A61K 9/5138 (2013.01); A61K 9/5153 (2013.01); A61K 9/5161 (2013.01); A61K 9/5169 (2013.01); A61K 38/2026 (2013.01); A61K 38/217 (2013.01); A61K 40/17 (2025.01); A61K 40/24 (2025.01); A61K 40/42 (2025.01); A61P 35/00 (2018.01); A61K 2239/49 (2023.05);
Abstract
Provided herein are polymeric particles and compositions (i.e., 'backpacks') that can adhere to cells and provide delivery of payload immunomodulatory agents to those cells. For examples, the particles can adhere to macrophages and/or monocytes and release cytokines that promote an M1 or M2 phenotype to improve therapeutic efficacy of the cells.