The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 16, 2025
Filed:
Oct. 17, 2022
Applicant:
Memorial Sloan-kettering Cancer Center, New York, NY (US);
Inventors:
Eric Pamer, Guilford, CT (US);
Charlie Buffie, New York, NY (US);
Peter Mckenney, New York, NY (US);
Assignee:
Memorial Sloan-Kettering Cancer Center, New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/74 (2015.01); A61K 38/44 (2006.01); A61K 45/06 (2006.01); C12N 9/00 (2006.01); C12N 9/04 (2006.01); C12Q 1/26 (2006.01);
U.S. Cl.
CPC ...
A61K 35/74 (2013.01); A61K 38/443 (2013.01); A61K 45/06 (2013.01); C12N 9/0006 (2013.01); C12Q 1/26 (2013.01); C12Y 101/01159 (2013.01);
Abstract
The present invention relates to methods and compositions for reducing the risk and severity ofinfection. It is based, at least in part, on the discovery that a restricted fraction of the gut microbiota, including the bacterium, contributes substantially to resistance againstinfection. Without being bound by any particular theory, it is believed that this is achieved through the biosynthesis of secondary bile acids.