The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 16, 2025
Filed:
Dec. 14, 2021
Applicant:
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Inventors:
Lynn Macdonald, Harrison, NY (US);
Andrew J. Murphy, Croton-on-Hudson, NY (US);
Vera Voronina, North Bethesda, MD (US);
Cagan Gurer, Chappaqua, NY (US);
Assignee:
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A01K 67/0278 (2024.01); C07K 14/74 (2006.01); C07K 14/705 (2006.01); C07K 14/73 (2006.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
A01K 67/0278 (2013.01); C07K 14/70539 (2013.01); A01K 2207/15 (2013.01); A01K 2217/072 (2013.01); A01K 2267/03 (2013.01); C07K 14/70514 (2013.01); C07K 14/70517 (2013.01); C12N 15/8509 (2013.01);
Abstract
The invention provides genetically modified non-human animals that express chimeric human/non-human MHC I and MHC II polypeptides and/or human or humanized β2 microglobulin polypeptide, as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided.