The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 09, 2025
Filed:
Sep. 26, 2019
Assistance Publique Hôpitaux DE Marseille, Marseilles, FR;
Inserm (Institut National DE LA Santé ET DE LA Recherche Médicale), Paris, FR;
Universite D'aix-marseille, Marseilles, FR;
Queen Mary University of London, London, GB;
Sorbonne Université, Paris, FR;
Aurélie Leroyer, Marseilles, FR;
Marcel Blot-Chabaud, Fuveau, FR;
Christos Chadjichristos, Villers Sous Saint Leu, FR;
Nathalie Bardin, Marseilles, FR;
Françoise Dignat-George, Marseilles, FR;
Alexandrine Bertaud, Marseilles, FR;
Benjamin Guillet, Aix En Provence, FR;
Christoph Thiemermann, Woodford Green, GB;
Guillaume Hache, Marseilles, FR;
UNIVERSITE D'AIX-MARSEILLE, Marseilles, FR;
ASSISTANCE PUBLIQUE HÔPITAUX DE MARSEILLE, Marseilles, FR;
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), Paris, FR;
QUEEN MARY UNIVERSITY OF LONDON, London, GB;
Abstract
The present invention relates to the field of medicine and in particular to the diagnostic and treatment of fibrosis. More particularly, the invention relates to CD146 and uses thereof as a biomarker in the diagnosis of fibrosis and as a therapeutic target in the treatment of fibrosis. The invention also relates to compositions and methods of detecting predisposition to, of diagnosing, prognosing and/or monitoring fibrosis in a subject. It further relates to CD146 inhibitors, and to compositions comprising a CD146 inhibitor, for use in prevention or treatment of fibrosis in a subject, as well as to compositions, kits and uses thereof in a diagnostic or therapeutic context.