The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 09, 2025
Filed:
Dec. 22, 2020
Applicant:
Translate Bio, Inc., Lexington, MA (US);
Inventors:
Frank Derosa, Lexington, MA (US);
Michael Heartlein, Lexington, MA (US);
Jonathan Abysalh, Lexington, MA (US);
Daniel Crawford, Lexington, MA (US);
Anusha Dias, Lexington, MA (US);
Shrirang Karve, Lexington, MA (US);
Assignee:
TRANSLATE BIO, INC., Waltham, MA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/10 (2006.01); C07H 21/04 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1003 (2013.01); C07H 21/04 (2013.01); C12N 15/1006 (2013.01); C12N 15/1017 (2013.01); C12N 15/1065 (2013.01); C12N 2310/10 (2013.01); C12Y 201/03003 (2013.01);
Abstract
The present invention relates, in part, to methods for large-scale purification of mRNA. The method includes, at least, a step of centrifuging an mRNA suspension in a centrifuge comprising a porous substrate at a speed sufficient to remove process contaminants and to precipitate purified mRNA composition onto the porous substrate.