The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 09, 2025
Filed:
Aug. 05, 2022
Applicant:
Rheinische Friedrich-wilhelms-universität Bonn, Bonn, DE;
Inventors:
Ulrich Matzner, Bonn, DE;
Volkmar Gieselmann, Alfter, DE;
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/16 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/16 (2013.01); C12Y 301/06001 (2013.01); A61K 38/00 (2013.01);
Abstract
The present invention pertains to a novel treatment of pathologies caused by an increased synthesis or accumulation of sulfolipids such as sulfatide. The invention provides mutated arylsulfatase A (ARSA or ASA, EC 3.1.6.8) enzymes with increased activity towards sulfatide metabolization. The invention provides nucleic acids encoding the mutant ARSA, the use of the proteins and nucleic acids, as well as pharmaceutical compositions comprising them, in the treatment of lysosomal storage disorders (LSDs) such as metachromatic leukodystrophy (MLD).