The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 09, 2025
Filed:
Oct. 28, 2019
Asymchem Laboratories (Tianjin) Co., Ltd., Tianjin, CN;
Hao Hong, Morrisville, NC (US);
Gage James, Morrisville, NC (US);
Yi Xiao, Tianjin, CN;
Yulei Ma, Tianjin, CN;
Na Zhang, Tianjin, CN;
Xuecheng Jiao, Tianjin, CN;
Huiyan Mu, Tianjin, CN;
Yibing Cheng, Tianjin, CN;
Shan Cao, Tianjin, CN;
ASYMCHEM LABORATORIES (TIANJIN) CO., LTD., Tianjin, CN;
Abstract
Provided are a transaminase mutant and use thereof. The transaminase mutant has an amino acid sequence obtained by mutation of an amino acid sequence shown in SEQ ID NO:1, the mutation at least includes one of the following mutation site combinations: T7C+S47C, Q78C+A330C, V137C+G313C, A217C+Y252C and L295C+C328C; or the transaminase mutant has an amino acid sequence which has the mutation sites in the mutated amino acid sequence and has 80% or more identity with the mutated amino acid sequence. The transaminase mutant realizes the change of protein structure and functions, reduces the enzyme amount, increases the enantiomeric excess (ee) value of a product, and reduces the difficulty of post-processing, so that the transaminase mutant may be suitable for industrial production.