The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 09, 2025
Filed:
May. 10, 2024
Genmab A/s, Valby, DK;
Biontech SE, Mainz, DE;
Kristel Kemper, Utrecht, NL;
Maarten Van Der Kroef, Utrecht, NL;
Dennis Verzijl, Utrecht, NL;
Andrea Gorlani, Utrecht, NL;
Pauline Linda De Goeje, Utrecht, NL;
Lars Guelen, Utrecht, NL;
David Satijn, Utrecht, NL;
Esther C. W. Breij, Utrecht, NL;
Ugur Sahin, Mainz, DE;
Sina Fellermeier-Kopf, Mainz, DE;
Maren Köhne, Mainz, DE;
Ganmab A/S, Valby, DK;
BioNTech SE, Mainz, DE;
Abstract
The present invention relates to antibodies capable of binding to human OX40 and to variants thereof comprising a modified Fc region comprising at least one mutation that enhances the Fc-Fc interaction of the antibody and at least one mutation that reduces the Fc effector functions of the antibody. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.