The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 09, 2025
Filed:
May. 22, 2020
Xiamen University, Xiamen, CN;
Yang Sheng Tang Company, Ltd., Hangzhou, CN;
Wenxin Luo, Xiamen, CN;
Can Wen, Xiamen, CN;
Xinchu Xiang, Xiamen, CN;
Jixian Tang, Xiamen, CN;
Yangtao Wu, Xiamen, CN;
Tianying Zhang, Xiamen, CN;
Quan Yuan, Xiamen, CN;
Ningshao Xia, Xiamen, CN;
XIAMEN UNIVERSITY, Xiamen, CN;
YANG SHENG TANG COMPANY, LTD., Hangzhou, CN;
Abstract
Disclosed are antibodies to anti-hepatitis B surface antigen (HBsAg) (especially humanized antibodies), nucleic acid molecules encoding same, methods for preparing same, and pharmaceutical compositions containing same. The antibodies have higher affinity for HBsAg at neutral pH than at acidic pH, thereby significantly enhancing the virus clearance efficiency and prolonging the virus inhibition time. The antibodies and the pharmaceutical compositions can be used for preventing and/or treating HBV infections or diseases related to HBV infections (e.g., hepatitis B), for neutralizing the virulence of HBV in a subject (e.g., a human), for reducing the serum level of HBV DNA and/or HBsAg in the body of the subject, or for activating the humoral immune response of the subject (e.g., a chronic HBV infected or chronic hepatitis B patient) against HBV.