The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 09, 2025

Filed:

Nov. 07, 2019
Applicants:

Orionis Biosciences, Inc., Waltham, MA (US);

Orionis Biosciences Bv, Ghent, BE;

Vib Vzw, Ghent, BE;

Universiteit Gent, Ghent, BE;

Inventors:

Nikolai Kley, Waltham, MA (US);

Jan Tavernier, Balegem, BE;

Anje Cauwels, Merelbeke, BE;

Lennart Zabeau, Zwijnaarde, BE;

Erik Depla, Zwijnaarde, BE;

Assignees:

Orionis Biosciences, Inc, Waltham, MA (US);

Orionis Biosciences BV, Ghent, BE;

VIB VZW, Ghent, BE;

Universiteit Gent, Ghent, BE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/56 (2006.01); A61P 35/00 (2006.01); C07K 14/565 (2006.01); C07K 16/28 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/56 (2013.01); A61P 35/00 (2018.01); C07K 14/565 (2013.01); C07K 16/2815 (2013.01); C07K 16/2818 (2013.01); C07K 16/2827 (2013.01); C07K 16/2851 (2013.01); C07K 16/2896 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01); C07K 2317/22 (2013.01); C07K 2317/31 (2013.01); C07K 2317/569 (2013.01); C07K 2317/71 (2013.01); C07K 2317/73 (2013.01); C07K 2317/76 (2013.01); C07K 2319/30 (2013.01); C07K 2319/33 (2013.01); C07K 2319/74 (2013.01);
Abstract

The present invention relates, in part, to agents, chimeric proteins and chimeric protein complexes that bind a plasmacytoid dendritic cell (pDC), e.g. Clec4C and their use as diagnostic and therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the pDC, e.g. Clec4C, binding agents, chimeric proteins, or chimeric protein complexes and their use in the treatment of various diseases, including autoimmune diseases.


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