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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12409249 B1

PDFFull Text
Date of Patent:
Sep. 09, 2025

Filed:

Nov. 26, 2019

Compositions and methods for immune tolerance

Applicants:

Massachusetts Institute of Technology, Cambridge, MA (US);

The General Hospital Corporation, Boston, MA (US);

Inventors:

Sangeeta N. Bhatia, Lexington, MA (US);

Arnav Chhabra, Cambridge, MA (US);

Marcela V. Maus, Lexington, MA (US);

Assignees:

Massachusetts Institute of Technology, Cambridge, MA (US);

The General Hospital Corporation, Boston, MA (US);

Attorneys:

McCarter & English, LLP

Jill Ann Mello

Primary Examiner:

Allison M Fox

Int. Cl.
CPC ...
A61L 27/36 (2006.01); A61K 35/12 (2015.01); A61K 35/33 (2015.01); A61K 35/407 (2015.01); A61K 35/44 (2015.01); A61L 27/22 (2006.01); A61L 27/38 (2006.01); A61L 27/52 (2006.01); C12N 5/071 (2010.01); C12N 5/077 (2010.01);
U.S. Cl.
CPC ...
A61L 27/3604 (2013.01); A61K 35/33 (2013.01); A61K 35/407 (2013.01); A61K 35/44 (2013.01); A61L 27/225 (2013.01); A61L 27/3683 (2013.01); A61L 27/3804 (2013.01); A61L 27/3808 (2013.01); A61L 27/3886 (2013.01); A61L 27/52 (2013.01); C12N 5/0656 (2013.01); C12N 5/067 (2013.01); C12N 5/069 (2013.01); A61K 2035/122 (2013.01); A61L 2430/40 (2013.01); C12N 2502/1323 (2013.01); C12N 2502/14 (2013.01); C12N 2502/28 (2013.01); C12N 2510/00 (2013.01); C12N 2533/56 (2013.01);
Abstract

Immunotolerant engineered human tissue constructs are provided that are suitable for implantation into subjects. In some embodiments, the immunotolerance is controllable by an inducible system. Methods of making and using the immunotolerant engineered tissue constructs are provided.

Find Patent Forward Citations

Bhatia, Sangeeta. (2025). Compositions and methods for immune tolerance (U.S. Patent No. 12409249). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12409249

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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