The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 09, 2025
Filed:
Jun. 22, 2020
University of Kentucky Research Foundation, Lexington, KY (US);
Memorial Sloan-kettering Cancer Center, New York, NY (US);
St. Jude Children's Research Hospital, Inc., Memphis, TN (US);
Hoshin Kim, Lexington, KY (US);
Rodney Kiplin Guy, Lexington, KY (US);
Jared T. Hammill, Lexington, KY (US);
Daniel Charles Scott, Marion, KY (US);
Brenda Arlene Schulman, Martinsried, DE;
Bhuvanesh Singh, Old Westbury, NY (US);
University of Kentucky Research Foundation, Lexington, KY (US);
Memorial Sloan-Kettering Cancer Center, New York, NY (US);
St. Jude Children's Research Hospital, Inc., Memphis, TN (US);
Abstract
A DCN1/2-mediated cullin neddylation modulator; a method for treating disorders associated with dysfunctional DCN1 and/or UBC12, Alzheimer's disease, other neurodegenerative diseases, bacterial infections, or viral infections; and a method for treating cancers are provided. The DCN1/2-mediated cullin neddylation modulator includes a compound according to Formula I disclosed herein. The methods include administering to a mammal a therapeutically effective amount of a compound according to Formula I. Also provided herein is a pharmaceutical composition including a therapeutically effective amount of a compound according to Formula I, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.