The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 09, 2025
Filed:
Apr. 22, 2020
Applicant:
The Cleveland Clinic Foundation, Cleveland, OH (US);
Inventor:
Vinod Labhasetwar, Solon, OH (US);
Assignee:
The Cleveland Clinic Foundation, Cleveland, OH (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 9/51 (2006.01); A61K 38/44 (2006.01); A61K 38/48 (2006.01);
U.S. Cl.
CPC ...
A61K 9/5153 (2013.01); A61K 38/446 (2013.01); A61K 38/482 (2013.01); C12Y 108/01007 (2013.01); C12Y 111/01006 (2013.01); C12Y 111/01009 (2013.01); C12Y 115/01001 (2013.01); C12Y 304/21068 (2013.01);
Abstract
Provided herein are compositions, systems, kits, and methods for treating a patient with a thromboembolism by administering nanoconjugates comprising nanoparticles encapsulating and/or conjugated to: i) tissue-type plasminogen activator (tPA), and ii) at least one antioxidant enzyme selected from the group consisting of: superoxide dismutase, glutathione peroxidase, glutathione reductase, and a catalase.