The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 02, 2025
Filed:
Dec. 30, 2022
Applicant:
Laboratory Corporation of America Holdings, Burlington, NC (US);
Inventor:
Robert Macneill, Monroe Township, NJ (US);
Assignee:
Laboratory Corporation of America Holdings, Burlington, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 30/72 (2006.01); B01D 15/30 (2006.01); B01D 15/42 (2006.01); G01N 30/00 (2006.01); G01N 30/14 (2006.01); G01N 30/88 (2006.01); G01N 30/02 (2006.01);
U.S. Cl.
CPC ...
G01N 30/7233 (2013.01); B01D 15/305 (2013.01); B01D 15/424 (2013.01); G01N 30/14 (2013.01); G01N 30/88 (2013.01); G01N 2030/009 (2013.01); G01N 2030/027 (2013.01); G01N 2030/8827 (2013.01);
Abstract
Disclosed herein are embodiments of methods for oligonucleotide analysis using a novel solid-phase extraction and hydrophilic-interaction liquid chromatography. The unique polar-based retention methods provided herein provide a high-recovery extraction. The methods improve assay reliability and reproducibility and reach picomolar sensitivity with the demonstrably beneficial accurate mass platform. Also disclosed herein are systems and computer program products for performing these methods.