The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 02, 2025

Filed:

Nov. 04, 2024
Applicant:

Caredx, Inc., Brisbane, CA (US);

Inventors:

Robert Woodward, Pleasanton, CA (US);

Marica Grskovic, Burlingame, CA (US);

James Yee, San Mateo, CA (US);

Mitch Nelles, Half Moon Bay, CA (US);

David Hiller, Brisbane, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 19/34 (2006.01); C12Q 1/6806 (2018.01); C12Q 1/686 (2018.01); G16B 20/00 (2019.01);
U.S. Cl.
CPC ...
C12Q 1/686 (2013.01); C12Q 1/6806 (2013.01); G16B 20/00 (2019.02);
Abstract

A method for sequencing can be used to monitor a recipient of an allograft. A sample comprising nucleic acid molecules can be provided from the recipient of the allograft. A plurality of nucleic acid molecules can be isolated from the sample and amplified. The plurality of nucleic acid molecules can be subjected to one or more amplification reactions using a plurality of primers to generate a plurality of DNA molecules. The plurality of primers can target at least 100 independent polymorphisms. The DNA molecules, or derivatives thereof, can be sequenced. The method may not require genotyping of the recipient.


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