The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 02, 2025
Filed:
Jul. 12, 2022
Applicant:
National University of Singapore, Singapore, SG;
Inventors:
Dario Campana, Singapore, SG;
Takahiro Kamiya, Singapore, SG;
Assignee:
NATIONAL UNIVERSITY OF SINGAPORE, Singapore, SG;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/0783 (2010.01); A61K 40/11 (2025.01); A61K 40/15 (2025.01); A61K 40/31 (2025.01); A61K 40/42 (2025.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0646 (2013.01); A61K 40/11 (2025.01); A61K 40/15 (2025.01); A61K 40/31 (2025.01); A61K 40/4211 (2025.01); A61K 40/4224 (2025.01); C07K 16/2809 (2013.01); C07K 16/2833 (2013.01); C07K 16/289 (2013.01); C12N 5/0636 (2013.01); A61K 2239/48 (2023.05); C07K 2319/03 (2013.01); C12N 2510/00 (2013.01);
Abstract
The present invention relates to a method of using a receptor (e.g., chimeric antigen receptor—CAR) that activates an immune response upon binding a cancer cell ligand in conjunction with a target-binding molecule that targets a protein or molecule for removal or neutralization to generate enhanced anti-cancer immune cells. The present invention also relates to engineered immune cells having enhanced therapeutic efficacy and uses thereof.